GM/CA CAT

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GM/CA-CAT Sponsors:
National Institute of General Medical Sciences (NIGMS) and National Cancer Institute (NCI) of the National Institutes of Health (NIH)

Entrance into one of GM/CA-CAT ID beamlines endstations

Sample environment with on-axis visualization and quad collimator allowing for one-click change of X-ray beam size

Footprints of selectable beam sizes on YAG: from 5µm to 300µm

Crystal imaging with on-axis hi-res video camera

$Polygon diffraction rastering with JBluIce$ $Staff displaying the first diffraction pattern (2004)$ Simulated radiation damage in a crystal hit by a micron-sized beam

Simulated radiation damage in a crystal hit by a micron-sized beam

Fluorescence rastering detects small crystals with minimum radiation exposure

Collecting data along vector with JBluIce

First structure of a complex between a G protein coupled receptor (GPCR) and its G protein revealed. Brian Kobilka group (Stanford University) and collaborators. <a href='news/highlights.html#Kobilka_2011'>Read more...</a>

First structure of a protein-activated GPCR. Ray Stevens group (The Scripps Research Institute) and collaborators. <a href='news/highlights.html#Stevens_2011'>Read more...</a>

Complex formation in the M1-fibrinogen network. Partho Ghosh group (University of California, San Diego) and collaborators. <a href='news/highlights.html#PGhosh_2011'>Read more...</a>

Structure of Mediator head module revealed. Yuichiro Takagi group (Indiana University School of Medicine) and collaborators. <a href='news/highlights.html#Takagi_2011'>Read more...</a>

A structure of the Sindis virus capsid. Michael Rossmann group (Purdue University) and colleagues. <a href='news/highlights.html#Rossmann_2011'>Read more...</a>

Allosteric activation of Protein Kinase C. James Hurley group (National Institutes of Health) and collaborators. <a href='news/highlights.html#JHurley_2011'>Read more...</a>

GM/CA CAT

The General Medicine and Cancer institutes Collaborative Access Team operates a national user facility for structural biology with synchrotron beamlines specializing in intense, tunable micro-beams for crystallography.

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Highlights

GM/CA CAT hosts 4th annual CCP4 School: From data collection to structure refinement and beyond. read more

GM/CA CAT wins R&D 100 award for 2010. see announcement read more

GM/CA-CAT rolls out Java-based version of popular BluIce data collection software. read more

Beamline Application: GM/CA-CAT supports five different categories of the user program. read more

NATURE Technology Feature: GM/CA CAT mini-beam allows matching beam & crystal sizes. read more

GM/CA CAT appeared on Chemical & Engineering News: New Beamlines Dedicated At Argonne

Sending a Message: How Receptors Talk to G Proteins. read more

Experiments at the GM/CA-CAT beamlines have resulted in many world-class results. read more

NATURE Technology Feature: GPCR structures solved using GM/CA CAT mini-beam. read more

GM/CA-CAT is an Office of Science User Facility operated for the U.S. Department of Energy Office of Science by Argonne National Laboratory

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